Exploiting novel process windows for synthesis of meso-substituted porphyrins under continuous flow conditions
Announcement posted by John Morris Group 01 Dec 2015
Researchers at Chemistry Department at the Federal University of Sao Carlos in Brazil were interested in transferring batch processes to continuous flow for the synthesis of a range of porphyrin compounds, using a Syrris Asia system.
Researchers from Universidade Federal de Sao Carlos and Universidade Federal de Rio de Janeiro have demonstrated the synthesis of a range of meso-substituted porphyrins under continuous flow conditions. This much improved method demonstrates the multi-gram scale-up of highly pure porphyrins in a safe, cost-effective, reproducible and robust manner.
Porphyrins are used in a wide variety of applications such as solar cells, catalysts, sensors and food dyes. Batch synthesis presents a challenge as porphyrin compounds are difficult to make and result in batches with low yields and purity.
Within 6 months of working on the system, Professor Kleber de Oliveira has spoken about his work on national TV in Brazil and also published his first paper on his porphyrin synthesis.
Abstract: Porphyrin synthesis by classical methods frequently involves the use of high temperatures, toxic and dangerous reagents yielding the product in very low amounts and with poor scalability. Herein, we have studied the synthesis of meso-substituted porphyrins under continuous flow conditions, thus demonstrating scale-up for the porphyrin synthesis in a safe, cost-competitive, highly pure, reproducible and robust manner.
To download the paper click here
This paper uses the Asia 120 System. Learn more about the product this chemistry was performed on:
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RSC Adv. 2015, 5, 84350-84355, DOI: 10.1039/C5RA16962C
Patricia B. Momo,a Barbara S. Bellete,a Timothy J. Brocksom,a Rodrigo O. M. A. de Souzab and Kleber T. de Oliveira*a
aUniversidade Federal de Sao Carlos, Departamento de Quımica, 13565-905, Sao Carlos, SP, Brazil.
bUniversidade Federal do Rio de Janeiro, Instituto de Quımica, 22941-909, Rio de Janeiro, Brazil.